A mutation in an acidic keratin in an epithelial cell leads to a fragile epithelial cell layer. Which of the following processes is most likely prevented by this mutation?
a) actin treadmillingb) nuclear lamina assemblyc) nuclear lamina disassemblyd) binding of keratin to cadherine) assembling keratin fibers

Answer :

Answer: d) binding of keratin to cadherine) assembling keratin fibers

Explanation:

The desmos (membrane domains that facilitates the cell-cell contact) like cadherins are able to provide the strong adhesion to the intermediate filaments between the epithelial cells and muscle cells. The binding of the cadherine with the keratin fibers helps in providing the strong connection and adhesion of cell to cell in epithelial cell layers.

Due to mutation of the acidic keratin epithelial cell a fragile epithelial cell layer develops this will lead to disassembly of the keratin epithelial cells or will prevent the assembly of the keratin epithelial cells.

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