Answer :
It is called Drug Antagonism.
Drug Antagonism is an interaction between two or more medications that have diametrically opposed physiological effects. Drug antagonists may prevent or lessen one or more medications' ability to work. Chemical antagonism is the process by which a drug interacts chemically with either a chemical or another drug, resulting in a diminished or nonexistent effect.
When two medications operating on various receptors and pathways have opposing effects on the same physiologic system, this is referred to as physiologic antagonism. Drugs that form drug-receptor complexes with their targets but do not activate or activate a response are known as antagonists.
They can stop the endogenous activator from binding to the receptor, preventing proper action (zero efficacy).
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