Answer :
In the beginning of the play, Lady Macbeth seems to be more
masculine or the one ‘wearing the pants’ in the play. She was the one who
suggested the murder of King Duncan. She also called on the spirits to unsex
her or to remove her femininity in order for her to effectively play her role
in the murder. However, afterwards the gender roles are shifted and Lady Macbeth
becomes submissive. She becomes unstable and unsure. She became insane because
she could not handle what she had done. Macbeth keeps secrets from her and goes
about in his killing spree.